Even though 3-MeO-PCP was once famously referred to as possessing opioid or dopaminergic action (based on early phenomenological Assessment), this supposition is contradicted by data demonstrating three-MeO-PCP to generally be a potent and selective ligand for that NMDA receptor with out considerable affinity to the µ-opioid receptor or dopamine transporter.
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Arylcyclohexylamines varyingly have NMDA receptor antagonistic, dopamine reuptake inhibitory, and μ-opioid receptor agonistic Houses. On top of that, σ receptor agonistic, nACh receptor antagonistic, and D2 receptor agonistic actions happen to be reported for Many of these agents. Antagonism in the NMDA receptor confers anesthetic, anticonvulsant, neuroprotective, and dissociative results; blockade from the dopamine transporter mediates stimulant and euphoriant results along with psychosis in large amounts; and activation of the μ-opioid receptor causes analgesic and euphoriant consequences.
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